Whereas San Diego has it’s fair share of weirdly pronounced words, Jamacha and Otay come to mind, most often if you use the Spanish pronunciation you’ll be correct. (Jamacha – the ch is like an sh, and Otay the y is really like an i, so more like Otai.) But this article gives some explanation for the unusual pronunciations of places the state of Colorado. Not that I’ll ever understand Zuni with a long i on the end.

Update – Fixed the link, let’s try this again.